Captain Ray Holt (Andre Braugher) takes over Brooklyn's 99th precinct, which includes Detective Jake Peralta (Andy Samberg), a talented but carefree detective who's used to doing whatever he wants. The other employees of the 99th precinct include Detective Amy Santiago (Melissa Fumero), Jake's over achieving and competitive partner; Detective Rosa Diaz (Stephanie Beatriz), a tough and kept to herself coworker; Detective Charles Boyle (Joe Lo Truglio), Jake's best friend who also has crush on Rosa; Detective Sergeant Terry Jeffords (Terry Crews), was recently taken off the field after the birth of his twin girls; and Gina Linetti (Chelsea Peretti), the precinct's sarcastic administrator.

The story of Bill Henrickson and his life in suburban Salt Lake City, balancing the needs of his three wives -- Barb, Nicki and Margene-- their seven kids, three new houses and the opening of his newest hardware store. When disturbing news arrives about Bill's father, he is forced to reconnect with his polygamist parents who live on a fundamentalist compound in rural Utah.